Human B cell chronic lymphocytic leukemia: immunohistochemical staining for ZAP-70 antigen. Note staining of malignant lymphocytic leukemic cells and intense staining of infiltrating T lymphocytes. ZAP-70: clone L453R

ZAP-70

zap-70

Antigen Background

ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.

Disclaimer

ZAP-70 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces ZAP-70-L-CE-S
    ZAP-70-L-CE
    1ml NCL-L-ZAP-70
    L453R
    Liquid Concentrate
    P (HIER)
  • PA0998
    7ml ZAP-70 Bond RTU Primary
    L453R
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

ZAP-70-L-CE
Hematopathology
L453R
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0998
Hematopathology
L453R
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

ZAP-70-L-CE
PA0998

Resources

Resources

Antigen Background

ZAP-70 is a member of the syk family of proteins. It is expressed on T cells and NK cells and is required for the T cell receptor activation that triggers an immune response. CLL B cells that express the non-mutated immunoglobulin VH genes express levels of ZAP-70 protein that are comparable to those found in the blood T cells of healthy adults. Leukemic cells that express mutated Ig VH genes generally do not express detectable levels of ZAP-70 protein and this is correlated with the high level expression of CD38.

Disclaimer

ZAP-70 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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