Neuron Specific Enolase
Enolase is a glycolytic enzyme catalyzing the reaction pathway between 2-phosphoglycerate and phosphoenol pyruvate. In mammals, enolase molecules are dimers composed of three distinct subunits (alpha, beta and gamma ) whereas, in rats, five forms have been found. The alpha subunit and beta subunit are of approximately 47 kD and 45 kD, respectively. The gamma gamma and alpha gamma enolases are located mainly in the nervous tissue and neuroendocrine cells.
Neuron Specific Enolase is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.