Colorectal carcinoma: immunohistochemical staining for mismatch repair protein (MSH2). Note nuclear staining in a high proportion of the malignant cells. Mismatch Repair Protein (MSH2): clone 79H11.

Mismatch Repair Protein (MSH2)

mismatch-repair-protein-msh2

Antigen Background

Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Therefore, the loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. MSH2 is reported to be expressed in the nuclei of cells from a variety of tissues including thyroid, heart, smooth muscle and the germinal centers of lymphoid follicles. In ileum and colon, MSH2 expression has been reported in the crypts, the cells which are undergoing rapid renewal. They are responsible for the continuous production of differentiated cells which migrate over 2 to 4 days before being sloughed into the lumen.

Disclaimer

Mismatch Repair Protein (MSH2) is a recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • MSH2-612-L-CE
    1ml NCL-L-MSH2-612
    79H11
    SDS
  • PA0048
    7ml MSH2 Bond RTU Primary
    25D12
    BOND RTU
    P (HIER)
  • PA0989
    7ml MSH2 (79H11) Bond RTU Primary
    79H11
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

MSH2-612-L-CE
79H11
In Vitro Diagnostic Use
PA0048
Gastrointestinal Pathology
25D12
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0989
Gastrointestinal Pathology
79H11
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

MSH2-612-L-CE
SDS
PA0048
PA0989

Resources

Resources

Antigen Background

Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Therefore, the loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. MSH2 is reported to be expressed in the nuclei of cells from a variety of tissues including thyroid, heart, smooth muscle and the germinal centers of lymphoid follicles. In ileum and colon, MSH2 expression has been reported in the crypts, the cells which are undergoing rapid renewal. They are responsible for the continuous production of differentiated cells which migrate over 2 to 4 days before being sloughed into the lumen.

Disclaimer

Mismatch Repair Protein (MSH2) is a recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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