Kip2 (p57 Protein)

kip2-p57-protein

Antigen Background

Cyclin dependent kinases are positive regulators of cell proliferation. p57 is an inhibitor of cyclin-dependent kinases, a tumour suppressor, and is involved in apoptosis and differentiation. It is closely-related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumours and tumours associated with the Beckwith-Wiedemann syndrome. There is increasing interest in p57 as a marker in Gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviours.

  • P57-L-CE
    1ml NCL-L-p57
    25B2
    Liquid Concentrate
    P (HIER)

Product Specifications

Product Specifications

P57-L-CE
Specialized
25B2
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml

Documents

Documents

P57-L-CE

Resources

Resources

Antigen Background

Cyclin dependent kinases are positive regulators of cell proliferation. p57 is an inhibitor of cyclin-dependent kinases, a tumour suppressor, and is involved in apoptosis and differentiation. It is closely-related to other CDKIs such as p21 protein (CIP1) and p27 protein (Kip1) as they share a common structural N-terminal domain for binding to CDK/cyclin complexes and inhibiting their kinase activity. Human p57 protein is found on chromosome 11p15.5, a region which is reported to be a common site for loss of heterozygosity in certain sarcomas, Wilms tumours and tumours associated with the Beckwith-Wiedemann syndrome. There is increasing interest in p57 as a marker in Gestational disease. Gestational trophoblastic disease refers to a spectrum of proliferative disorders of the placental trophoblast, with a wide range of histologic appearances and clinical behaviours.

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