Invasive breast carcinoma: immunohistochemical staining for Gross Cystic Disease Fluid Protien-15. Note to cytoplasmic staining in tumor cells. Gross Cystic Disease Fluid Protein-15: clone 23A3

Gross Cystic Disease Fluid Protein-15

gross-cystic-disease-fluid-protein-15

Antigen Background

Gross cystic disease of the breast is a benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive apocrine cystic secretions. This fluid is composed of several glycoproteins including a unique 15 kD monomer protein, GCDFP15. It has been reported that cytosolic analysis of normal tissue from all major organs has demonstrated GCDFP15 in apocrine epithelia, lacrimal, ceruminous and Moll's glands and in numerous serous cells of the submandibular, tracheal, bronchial, sublingual and minor salivary glands. Cytosol from breast carcinoma lesions are reported to contain GCDFP15 at a wide range of concentrations. The concentration is reported to be highest in more differentiated carcinomas and GCDFP15 shows only a few positive individual epithelial cells within lobules and small ducts in normal breast. Expression has also been reported in fibroadenomas within areas of apocrine metaplasia.

Disclaimer

Gross Cystic Disease Fluid Protein-15 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • GCDFP15-L-CE
    1ml NCL-L-GCDFP15
    23A3
    Liquid Concentrate
    P (HIER)
  • PA0708
    7ml GCDFP15 Bond RTU Primary
    23A3
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

GCDFP15-L-CE
Breast Pathology
23A3
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0708
Breast Pathology
23A3
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

GCDFP15-L-CE
PA0708

Resources

Resources

Antigen Background

Gross cystic disease of the breast is a benign premenopausal disorder in which cysts are a predominant pathological lesion. These cysts appear to be formed from excessive apocrine cystic secretions. This fluid is composed of several glycoproteins including a unique 15 kD monomer protein, GCDFP15. It has been reported that cytosolic analysis of normal tissue from all major organs has demonstrated GCDFP15 in apocrine epithelia, lacrimal, ceruminous and Moll's glands and in numerous serous cells of the submandibular, tracheal, bronchial, sublingual and minor salivary glands. Cytosol from breast carcinoma lesions are reported to contain GCDFP15 at a wide range of concentrations. The concentration is reported to be highest in more differentiated carcinomas and GCDFP15 shows only a few positive individual epithelial cells within lobules and small ducts in normal breast. Expression has also been reported in fibroadenomas within areas of apocrine metaplasia.

Disclaimer

Gross Cystic Disease Fluid Protein-15 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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