Human tonsil: immunohistochemical staining for Cyclin D1. Note nuclear staining of a subset of proliferating epithelial cells. Cyclin D1: clone EP12
New Picture: Human mantle cell lymphyoma: nuclear staining of the malignant post-germinal B lymphocytes. Cyclin D1: colne EP12

Cyclin D1

cyclin-d1

Antigen Background

The D-type cyclins are a family of proteins which function primarily by regulating the activity of cyclin dependent kinases in the G1 phase of the cell cycle. Cyclin D1, a protein of 36 kD, is also known as PRAD1 or bcl-1. Maximum expression of cyclin D1 occurs at a critical point in mid to late G1 phase of the cell cycle. The cyclin D1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphomas due to the chromosomal translocation t(11;18).

Disclaimer

Cyclin D1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • CYCLIND1-GM-L
    1ml NCL-L-CYCLIND1-GM
    P2D11F11
    Liquid Concentrate
    P (ENZYME/HIER)
  • CYCLIND1-GM-L-CE
    1ml NCL-L-CYCLIND1-GM
    P2D11F11
    Liquid Concentrate
    P (ENZYME/HIER)
  • PA0046
    7ml Cyclin D1 (EP12) Bond RTU Primary
    EP12
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CYCLIND1-GM-L
Hematopathology
P2D11F11
Liquid Concentrate
No
P (ENZYME/HIER)
Mono
Mouse
Research Use Only
1ml
CYCLIND1-GM-L-CE
Hematopathology
P2D11F11
Liquid Concentrate
No
P (ENZYME/HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0046
Hematopathology
EP12
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CYCLIND1-GM-L
CYCLIND1-GM-L-CE
PA0046

Resources

Resources

Antigen Background

The D-type cyclins are a family of proteins which function primarily by regulating the activity of cyclin dependent kinases in the G1 phase of the cell cycle. Cyclin D1, a protein of 36 kD, is also known as PRAD1 or bcl-1. Maximum expression of cyclin D1 occurs at a critical point in mid to late G1 phase of the cell cycle. The cyclin D1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphomas due to the chromosomal translocation t(11;18).

Disclaimer

Cyclin D1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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