Human lymph node, nodular sclerosing Hodgkin's disease: immunohistochemical staining for CD30. Note membrane and cytoplasmic staining of the neoplastic cells, CD30: clone JCM182

CD30

cd30

Antigen Background

The CD30 antigen is a single chain glycoprotein with a molecular weight of 120 kD. CD30 antigen is known to act as a receptor for a cytokine ligand, CD30L, and may also play a role in the regulation of cellular growth and transformation. CD30 antigen is reported to be expressed on the surface of multinucleated Reed Sternberg cells, mononuclear Hodgkin's cells and in the majority of anaplastic large cell lymphomas. The CD30 antigen is expressed in non-Hodgkin's lymphoma and virally transformed cells, for example, EBV-transformed B cells.

Product Specific Information 

Using retrieval solutions other than that recommended for clone JCM182 in the datasheet may increase background reactivity.

Disclaimer

CD30 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

  • CD30-591-L
    1ml NCL-L-CD30-591
    JCM182
    Liquid Concentrate
    P (HIER)
  • CD30-591-L-CE
    1ml NCL-L-CD30-591
    JCM182
    Liquid Concentrate
    P (HIER)
  • PA0790
    7ml CD30 (JCM182) Bond RTU Primary
    JCM182
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CD30-591-L
Hematopathology
JCM182
Liquid Concentrate
No
P (HIER)
Mono
Mouse
Research Use Only
1ml
CD30-591-L-CE
Hematopathology
JCM182
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0790
Hematopathology
JCM182
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CD30-591-L
CD30-591-L-CE
PA0790

Resources

Resources

Antigen Background

The CD30 antigen is a single chain glycoprotein with a molecular weight of 120 kD. CD30 antigen is known to act as a receptor for a cytokine ligand, CD30L, and may also play a role in the regulation of cellular growth and transformation. CD30 antigen is reported to be expressed on the surface of multinucleated Reed Sternberg cells, mononuclear Hodgkin's cells and in the majority of anaplastic large cell lymphomas. The CD30 antigen is expressed in non-Hodgkin's lymphoma and virally transformed cells, for example, EBV-transformed B cells.

Product Specific Information 

Using retrieval solutions other than that recommended for clone JCM182 in the datasheet may increase background reactivity.

Disclaimer

CD30 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

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