Human liver: immunohistochemical staining for CD13. Note staining of the bile canniculi. CD13: clone 38C12

CD13

cd13

Antigen Background

CD13 antigen, also known as aminopeptidase N, is a member of type II integral membrane metalloproteases, which also includes the leukocyte antigens CD10, CD26, CD73 and BP-1. CD13 antigen is a receptor for the coronaviruses which cause respiratory disease in humans and several animal species. The antigen functions as a zinc-binding metalloprotease which plays a role in cell surface antigen presentation by trimming the N-terminal amino acids from MHC class II-bound peptides. CD13 antigen is reported to be expressed on granulocytes, monocytes and their precursors, most acute myeloid leukemias and a smaller proportion of acute lymphoid leukemias. Non-hematopoietic cells which express CD13 antigen include epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi.

Disclaimer

CD13 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

  • CD13-304-L-CE
    1ml NCL-L-CD13-304
    38C12
    Liquid Concentrate
    P (HIER)
  • PA0304
    7ml CD13 (38C12) Bond RTU Primary
    38C12
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CD13-304-L-CE
Hematopathology
38C12
Liquid Concentrate
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0304
Hematopathology
38C12
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CD13-304-L-CE
PA0304

Resources

Resources

Antigen Background

CD13 antigen, also known as aminopeptidase N, is a member of type II integral membrane metalloproteases, which also includes the leukocyte antigens CD10, CD26, CD73 and BP-1. CD13 antigen is a receptor for the coronaviruses which cause respiratory disease in humans and several animal species. The antigen functions as a zinc-binding metalloprotease which plays a role in cell surface antigen presentation by trimming the N-terminal amino acids from MHC class II-bound peptides. CD13 antigen is reported to be expressed on granulocytes, monocytes and their precursors, most acute myeloid leukemias and a smaller proportion of acute lymphoid leukemias. Non-hematopoietic cells which express CD13 antigen include epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi.

Disclaimer

CD13 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

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