Anaplastic large cell lymphoma: immunohistochemical staining for ALK. Note the strong nuclear and cytoplasmic staining in the neoplastic cells. ALK: clone 5A4

ALK

alk

Antigen Background

Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.

Disclaimer

ALK is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
 

  • ALK-L-H
    0.5ml NCL-L-ALK
    5A4
    Liquid Concentrate
    P (HIER)
  • ALK-L-CE-H
    0.5ml NCL-L-ALK
    5A4
    Liquid Concentrate
    P (HIER)
  • PA0306
    7ml ALK Bond RTU Primary
    5A4
    BOND RTU
    P (HIER)
  • PA0831
    7 mL ALK (5A4) BOND RTU Primary
    5A4
    SDS(pdf)

Product Specifications

Product Specifications

ALK-L-H
Hematopathology
5A4
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
0.5ml
ALK-L-CE-H
Hematopathology
5A4
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
0.5ml
PA0306
Hematopathology
5A4
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0831
5A4
In Vitro Diagnostic Use

Documents

Documents

ALK-L-H
ALK-L-CE-H
PA0306
PA0831
SDS(pdf)

Resources

Resources

Antigen Background

Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.

Disclaimer

ALK is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
 

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