Acquired deletions of the long arm of chromosome 20 are found in several hematologic Conditions and particularly in the myeloproliferative disorders (MPD) and myelodysplastic syndromes and acute myeloid leukemia (MDS/AML). A minimal critical region deleted in MPD and MDS has been identified at 20q12 which includes a protein tyrosine phosphatase receptor gene (PTPRT).
A 20q11 region specific probe is included to facilitate chromosome identification.
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