1q21 / SRD (1p36)
Frequent loss of heterozygosity (LOH) on the short arm of chromosome 1 (1p) has been reported in a series of human malignancies. The combination with the potentially amplified 1q21 region allows to detect deletions at 1p36 and gain of 1q21 in a single FISH assay.
1q21 / 8p21
Amplifications of 1q21 are concurrent with dysregulated expression of MAF, WHSC1/FGFR3, or del(13) and represent an independent unfavorable prognostic factor. Allelic losses of the chromosome 8p21-22 have been reported as a frequent event in several cancers.
Cremer et al. 2005, Genes Chrom Cancer, 44: 194-203.
Shaughnessy J., 2005, Hematology, 10 suppl 1: 117-126.