Squamous cell carcinoma: immunohistochemical staining of p21(WAF1): clone 4D10

p21 (WAF1 Protein)

p21-waf1-protein

Antigen Background

The gene encoding WAF1, also termed p21, is transcriptionally regulated by the suppressor protein, p53. Overexpression of WAF1 is growth suppressive, possibly by inhibiting the activity of cyclin/CDK complexes. One consequence of WAF1 binding to cyclin/CDK is the inhibition of Rb protein phosphorylation. Induction of WAF1 expression requires wild type p53 activity in cells undergoing p53 dependent G1 arrest or apoptosis. Mutation of the p53 gene is a common event in human cancer and results in the failure to produce WAF1. The effect of this may lead to uncontrolled cell proliferation.

Disclaimer

p21 (WAF1 Protein) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces WAF-1WAF-1-L-UWAF-1-S
    WAF-1-L
    1ml NCL-L-WAF-1
    4D10
    Liquid Concentrate
    P (HIER)

Product Specifications

Product Specifications

WAF-1-L
Specialized
4D10
Liquid Concentrate
No
P (HIER)
Mono
Mouse
Research Use Only
1ml

Documents

Documents

WAF-1-L

Resources

Resources

Antigen Background

The gene encoding WAF1, also termed p21, is transcriptionally regulated by the suppressor protein, p53. Overexpression of WAF1 is growth suppressive, possibly by inhibiting the activity of cyclin/CDK complexes. One consequence of WAF1 binding to cyclin/CDK is the inhibition of Rb protein phosphorylation. Induction of WAF1 expression requires wild type p53 activity in cells undergoing p53 dependent G1 arrest or apoptosis. Mutation of the p53 gene is a common event in human cancer and results in the failure to produce WAF1. The effect of this may lead to uncontrolled cell proliferation.

Disclaimer

p21 (WAF1 Protein) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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