Colonic adenocarcinoma: immunohistochemical staining for Sialyl Lewis antigen. Note the enhancement of the luminal membrane staining of colonic epithelial cells. CA19-9: clone C241:5:1:4

CA19-9 (Sialyl Lewis a)

ca19-9-sialyl-lewis-a

Antigen Background

CA19-9 is an epitope on the sialylated Lewisa carbohydrate structure. Sialylated Lewisa plays a role in cell adhesion by acting as a functional ligand for the inducible adhesion molecule E-selectin. CA19-9 and CA50 (carcinoma associated mucin antigen) are useful serum markers in the diagnosis and follow up of gastrointestinal and pancreatic cancers. In carcinoma of the pancreas, it is reported that the immunohistochemical expression of both CA19-9 and CA50 correlates with tumor differentiation, where the strongest staining is observed in well-differentiated tumors. These two markers are also reported in a number of benign lesions such as chronic pancreatitis.

Product Specific Information

Clone C241:5:1:4 reacts specifically with Sialyl Lewisa - containing glycolipids, showing no crossreaction with Lewisa, Lewisb, or other structurally related molecules. The epitope recognized by NCL-L-CA19-9 is designated CA19-9.

Disclaimer

CA19-9 (Sialyl Lewisa) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

  • CA19-9-L
    1ml NCL-L-CA19-9
    C241:5:1:4
    Liquid Concentrate
    P (HIER)
  • This item replaces CALP
    PA0424
    7ml CA19-9 Bond RTU Primary
    C241:5:1:4
    BOND RTU
    P (HIER)

Product Specifications

Product Specifications

CA19-9-L
Gastrointestinal Pathology
C241:5:1:4
Liquid Concentrate
No
P (HIER)
Mono
Mouse
Research Use Only
1ml
PA0424
Gastrointestinal Pathology
C241:5:1:4
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Documents

Documents

CA19-9-L
PA0424

Resources

Resources

Antigen Background

CA19-9 is an epitope on the sialylated Lewisa carbohydrate structure. Sialylated Lewisa plays a role in cell adhesion by acting as a functional ligand for the inducible adhesion molecule E-selectin. CA19-9 and CA50 (carcinoma associated mucin antigen) are useful serum markers in the diagnosis and follow up of gastrointestinal and pancreatic cancers. In carcinoma of the pancreas, it is reported that the immunohistochemical expression of both CA19-9 and CA50 correlates with tumor differentiation, where the strongest staining is observed in well-differentiated tumors. These two markers are also reported in a number of benign lesions such as chronic pancreatitis.

Product Specific Information

Clone C241:5:1:4 reacts specifically with Sialyl Lewisa - containing glycolipids, showing no crossreaction with Lewisa, Lewisb, or other structurally related molecules. The epitope recognized by NCL-L-CA19-9 is designated CA19-9.

Disclaimer

CA19-9 (Sialyl Lewisa) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains. 

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