BCL6 (3q27) Break probe hybridized to patient material (1RG1R1G). Image kindly provided by Prof. Siebert, Kiel.
RUO - BCL6 Break
Chromosomal translocations involving band 3q27 with various different partner chromosomes represent a recurrent cytogenetic abnormality in B-cell non-Hodgkin's lymphoma. Kreatech has developed this probe for the specific use on cell material (KBI-10607), or on tissue (KBI-10730). Two different breakpoint regions have been identified; the major breakpoint region (MBR) is located within the 5' noncoding region of the BCL6 proto-oncogene, while the atypical breakpoint region (ABR) is located approximately 200 kb distal to the BCL6 gene. The BCL6 (3q27) Break FISH probe is designed in a way to flank both possible breakpoints, thereby providing clear split signals in either case.
References: Butler et al, 2002, Cancer Res, 62; 4089-4094. Sanchez-Izquierdo, 2001, Leukemia, 15; 1475-1484.