FGFR1 (8p11) Break probe hybridization to a tissue section showing a normal pattern.
IVD FGFR1 Break
FGFR1 has been implicated in the tumorigenesis of haematological malignancies, where it is frequently involved in balanced chromosomal translocations, including cases of chronic myeloid leukemia (BCR-FGFR1 fusion) and the 8p11 myeloproliferative syndrome/stem cell leukemia-lymphoma syndrome, which is characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, the most common being a fusion between ZNF198 and FGFR1. The FGFR1 (8p11) Break FISH probe is optimized to detect translocations involving the FGFR1 gene region at 8p11 in a dual-color assay on FFPE tissue sections.
References: Smedley et al, 1998, Hum Mol Genet., 7; 627-642. Sohal et al, 2001, Genes Chrom. Cancer, 32; 155-163. Kwak et al, J Clin Oncol., 27(26); 4247-53.