5q

5q

The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. Interstitial 5q deletions are the most frequent chromosomal abnormalities in MDS and are present in 10% to15% of MDS patients. Two different critical regions are described, one at 5q31-q33 containing the CSF1R and RPS14 gene regions, characteristic for the ‘5q-‘ syndrome, and a more proximal located region at 5q13-q31 containing the CDC25C and EGR1 gene regions.

References:

Boultwood J e.a., Blood 2002; 99: 4638-4641.
Zhao N e.a., PNAS 1997; 94: 6948-6953.
Wang e.a., Haematologica 2008; 93: 994-1000 .
Ebert BL e.a., Nature 2008: 451: 335-339.
Mohamedali A and Mufti GJ, Brit J Haematol 2008; 144: 157-168.

  • KBI-10209
    5q- (5q31; 5q33)
  • KBI-10210
    5q- (5q31; 5q33) / TERT (5p15) TC
  • KI-10209
    5q- (5q31; 5q33)
  • KI-10210
    5q- (5q31; 5q33) / TERT (5p15) TC

Produktspezifikationen

Produktspezifikationen

KBI-10209
Hematopathology
In Vitro Diagnostic Use
10 test
Dual Color > Red, Green
Cells
Deletion
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KBI-10210
Hematopathology
In Vitro Diagnostic Use
10 test
Triple Color > Red, Blue, Green
Cells
Deletion
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KI-10209
Research
Research Use Only
10 test
Dual Color > Red, Green
Cells
Deletion
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent
KI-10210
Research
Research Use Only
10 test
Triple Color > Red, Blue, Green
Cells
Deletion
Gene Region-Specific
Fluorescent
Ready-to-Use
Manual Reagent

Dokumente

Dokumente

Ressourcen

Ressourcen

The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. Interstitial 5q deletions are the most frequent chromosomal abnormalities in MDS and are present in 10% to15% of MDS patients. Two different critical regions are described, one at 5q31-q33 containing the CSF1R and RPS14 gene regions, characteristic for the ‘5q-‘ syndrome, and a more proximal located region at 5q13-q31 containing the CDC25C and EGR1 gene regions.

References:

Boultwood J e.a., Blood 2002; 99: 4638-4641.
Zhao N e.a., PNAS 1997; 94: 6948-6953.
Wang e.a., Haematologica 2008; 93: 994-1000 .
Ebert BL e.a., Nature 2008: 451: 335-339.
Mohamedali A and Mufti GJ, Brit J Haematol 2008; 144: 157-168.

Zuletzt angesehen

Alle anzeigen