Human invasive ductal carcinoma of breast: immunohistochemical staining for AE1/AE3. Note the intense staining of malignant cells. Multi-Cytokeratin: clone AE1/AE3

Multi-Cytokeratin (AE1, AE3)

multi-cytokeratin-ae1-ae3

Antigen Background

Keratins are a family of water insoluble proteins of 40 to 70 kD. These proteins form tonofilaments, a class of intermediate filament, in epidermis as well as in almost all other epithelia. The process of normal epidermal differentiation is characterized by a series of morphological and biochemical changes as cells progress from the germinative basal layer through the spinous and granular layers to the outer cornified layer. The 65 to 67 kD cytokeratins are reported to be present only above the basal layer, the 58 kD cytokeratin is reported to be expressed throughout the entire epidermis including the basal layer and the 56 kD cytokeratin is reported to be absent from the basal layer and is normally eliminated during stratum corneum formation. The 56 and 65 to 67 kD cytokeratins are reported to be characteristic of epidermal cells undergoing terminal differentiation and may be considered as molecular markers for keratinization.

Cytokeratin, Multi (AE1/AE3) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Product Specific Information

Clones AE1 and AE3 are specific for the 56.5, 50, 50', 48 and 40 kD acidic cytokeratins as well as the 65 to 67, 64, 59, 58, 56 and 52 kD basic cytokeratins. The cocktail of clones AE1 and AE3 exhibit broad reactivity with two families of cytokeratin, acidic and basic.

  • AE1/AE3-L-CE
    1ml NCL-L-AE1/AE3
    AE1/AE3
    Liquid Concentrate
    P (HIER)
  • AE1/AE3-601-L-CE
    1ml NCL-L-AE1/AE3-601
    AE1/AE3
    Liquid Concentrate
    P (HIER)
  • PA0909
    7ml AE1/AE3 Bond RTU Primary
    AE1/AE3
    BOND RTU
    P (ENZYME)
  • PA0094
    7ml Cytokeratin (AE1/AE3) BOND RTU
    AE1/AE3
    BOND RTU
    P (HIER)
  • PA0012
    7ml Multi-Cytokeratin Bond RTU Primary
    AE1/AE3
    BOND RTU
    P (HIER)

Produktspezifikationen

Produktspezifikationen

AE1/AE3-L-CE
Tumor Differentiation
AE1/AE3
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
AE1/AE3-601-L-CE
Tumor Differentiation
AE1/AE3
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0909
Tumor Differentiation
AE1/AE3
BOND RTU
Yes
P (ENZYME)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0094
Tumor Differentiation
AE1/AE3
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml
PA0012
Tumor Differentiation
AE1/AE3
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use

Dokumente

Dokumente

Ressourcen

Ressourcen

Antigen Background

Keratins are a family of water insoluble proteins of 40 to 70 kD. These proteins form tonofilaments, a class of intermediate filament, in epidermis as well as in almost all other epithelia. The process of normal epidermal differentiation is characterized by a series of morphological and biochemical changes as cells progress from the germinative basal layer through the spinous and granular layers to the outer cornified layer. The 65 to 67 kD cytokeratins are reported to be present only above the basal layer, the 58 kD cytokeratin is reported to be expressed throughout the entire epidermis including the basal layer and the 56 kD cytokeratin is reported to be absent from the basal layer and is normally eliminated during stratum corneum formation. The 56 and 65 to 67 kD cytokeratins are reported to be characteristic of epidermal cells undergoing terminal differentiation and may be considered as molecular markers for keratinization.

Cytokeratin, Multi (AE1/AE3) is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Product Specific Information

Clones AE1 and AE3 are specific for the 56.5, 50, 50', 48 and 40 kD acidic cytokeratins as well as the 65 to 67, 64, 59, 58, 56 and 52 kD basic cytokeratins. The cocktail of clones AE1 and AE3 exhibit broad reactivity with two families of cytokeratin, acidic and basic.

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