Human breast: invasive ductal carcinoma: immunohistochemical staining for c-erbB-2 Oncoprotein (HER-2): clone CB11

c-erbB-2 Oncoprotein (HER-2)

c-erbb-2-oncoprotein-her-2

Antigen Background

The c-erbB-2 oncoprotein is closely related in structure to the epidermal growth factor receptor and is a member of a large family of cell surface growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable in a proportion of breast and other adenocarcinomas as well as transitional cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell types in a range of normal human fetal and adult tissues, including breast, stomach and ovary. CB11 detects the internal domain of the c-erbB-2 oncoprotein. CBE-356 detects the external domain of the c-erbB-2 oncoprotein.

Product Specific Information

CB11 is effective with no pretreatment on fixed, paraffin-embedded tissue but the use of the heat induced epitope retrieval (HIER) technique may enhance staining in some cases.
Intended Use
This reagent is for in vitro diagnostic use. The c-erbB-2 Oncoprotein (CB11) monoclonal antibody is intended to be used for the qualitative identification by light microscopy of c-erbB-2 oncoprotein in formalin-fixed, paraffin-embedded tissue by immunohistochemical staining.

Disclaimer

c-erbB-2 Oncoprotein (HER-2) Antibodies are recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

  • This item replaces CB11C-ERBB-2-316CB11-SCB11-R-7C-ERBB-2-316-CE-CB11-CEC-ERBB-2-316-CECB11-CE-SCB11-L
    CB11-L-CE
    1ml NCL-L-CB11
    CB11
    Liquid Concentrate
    P
  • This item replaces CBE-356-R-7-CECBE-356-CECBE-356-CE-S
    CBE-356-L-CE
    1ml NCL-L-CBE-356
    10A7
    Liquid Concentrate
    P
  • PA0571
    13.5 mL c-erbB-2 Oncoprotein BOND RTU
    CB11
    BOND RTU
    P (HIER)
  • PA0983
    7 mL c-erbB-2 Oncoprotein BOND RTU
    CB11
    BOND RTU
    P (HIER)

Produktspezifikationen

Produktspezifikationen

CB11-L-CE
Breast Pathology
CB11
Liquid Concentrate
No
P
Mono
Mouse
In Vitro Diagnostic Use
1ml
CBE-356-L-CE
Breast Pathology
10A7
Liquid Concentrate
No
P
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0571
Breast Pathology
CB11
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
13.5ml
PA0983
Breast Pathology
CB11
BOND RTU
No
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Dokumente

Dokumente

Ressourcen

Ressourcen

Antigen Background

The c-erbB-2 oncoprotein is closely related in structure to the epidermal growth factor receptor and is a member of a large family of cell surface growth factor receptors. c-erbB-2 oncoprotein is reported to be detectable in a proportion of breast and other adenocarcinomas as well as transitional cell carcinomas. c-erbB-2 oncoprotein is present in a wide variety of cell types in a range of normal human fetal and adult tissues, including breast, stomach and ovary. CB11 detects the internal domain of the c-erbB-2 oncoprotein. CBE-356 detects the external domain of the c-erbB-2 oncoprotein.

Product Specific Information

CB11 is effective with no pretreatment on fixed, paraffin-embedded tissue but the use of the heat induced epitope retrieval (HIER) technique may enhance staining in some cases.
Intended Use
This reagent is for in vitro diagnostic use. The c-erbB-2 Oncoprotein (CB11) monoclonal antibody is intended to be used for the qualitative identification by light microscopy of c-erbB-2 oncoprotein in formalin-fixed, paraffin-embedded tissue by immunohistochemical staining.

Disclaimer

c-erbB-2 Oncoprotein (HER-2) Antibodies are recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

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