Human diffuse large B cell lymphoma: The majority of neoplastic cells show a moderate to strong nuclear staining reaction. Bcl-6: clone LN22

Bcl-6 Oncoprotein

bcl-6-oncoprotein

Antigen Background

Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

Disclaimer

Bcl-6 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
  • This item replaces BCL-6
    BCL-6-564-L
    1ml NCL-L-Bcl-6-564
    LN22
    Liquid Concentrate
    P (HIER)
  • This item replaces BCL-6-564-L-SBCL-6-564-L-CE-SBCL-6-S
    BCL-6-564-L-CE
    1ml NCL-L-Bcl-6-564
    LN22
    Liquid Concentrate
    P (HIER)
  • PA0204
    7ml Bcl-6 Bond RTU Primary
    LN22
    BOND RTU
    P (HIER)

Produktspezifikationen

Produktspezifikationen

BCL-6-564-L
Hematopathology
LN22
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
Research Use Only
1ml
BCL-6-564-L-CE
Hematopathology
LN22
Liquid Concentrate
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
1ml
PA0204
Hematopathology
LN22
BOND RTU
Yes
P (HIER)
Mono
Mouse
In Vitro Diagnostic Use
7ml

Dokumente

Dokumente

Ressourcen

Ressourcen

Antigen Background

Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal center B cells and related lymphomas. It has been shown that the Bcl-6 proto-oncogene is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

Disclaimer

Bcl-6 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Zuletzt angesehen

Alle anzeigen