IVD CCND1 Break

Overexpression of the Cyclin D1 gene caused by amplification or translocation is described for several types of cancer. A t(11;14) is the main characteristic aberration in mantle cell lymphoma (documented in 40-70% of the cases. In MM, the same translocation t(11;14)(q13:q32) is the most common, with a reported frequency of 15% to 20% of the cases.
Kreatech has developed this probe to detect rearrangements of the CCND1 gene region at 11q13 (KBI-10609) or for the translocation t(11;14) in Mantle Cell Lymphoma (KBI-10604) and for MM (KBI-10605). The CCND1 (11q13) Break FISH probe is optimized to detect translocations involving the CCND1 gene region at 11q13 in a dual-color, split assay on metaphase/interphase spreads.

References:
Vaandrager et al, 1996, Blood, 88; 1177-1182.
Vaandrager et al, Blood, 89; 349-350.