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Antigen Background
The muscle-specific form of laminin, merosin, is composed of three chains: alpha 2, beta 1 and gamma 1.
Mutations in the chromosome 6 encoded gene for the laminin alpha 2 chain of merosin are responsible for a form of congenital muscular dystrophy (CMD). Merosin-negative CMD is characterized by a severe clinical phenotype and is associated with white matter changes on brain imaging.
Disclaimer
Merosin Laminin Alpha 2 Chain is recommended for the detection of specific antigens of interest in normal and abnormal tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
