MYEOV / IGH t(11;14) Fusion probe hybridized to MM patient material showing t(11;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.
MYEOV / IGH t(11;14) Fusion probe hybridized to MM patient material showing t(11;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.
IVD MYEOV/IGH
The most common chromosomal translocation in multiple myeloma (MM) is t(11;14), resulting in up-regulation of cyclin D1. In MM the breakpoints are scattered within a 360-kb region between CCND1 and MYEOV. This breakpoint is more proximal than the t(11;14) breakpoints observed in mantle cell lymphoma or other leukemias. Patients with MM who have t(11;14)(q13;q32) seem to have an aggressive clinical course. The MYEOV/IGH t(11;14)(q13;q32) Fusion specific FISH probe is optimized to detect the reciprocal translocation t(11;14) in a dual-color, dual-fusion assay.
References: Janssen et al., 2000, Blood, 95; 2691-2698. Fonseca et al, 2002, Blood, 99; 3735-3741.
产品
产品
KBI-10605
MYEOV/IGH t(11;14) Fusion
Product is out of stock
Due to manufacturing & supply chain issues, this product is currently unavailable. You may place your order and it will be fulfilled when the product is back in stock. For more help, please reach out to customer service at +1 844 534 2262 or nonurgentcs@leicabiosystems.com
Product is limited in stock
Product availability is limited, but products are in continuous production. Your order will be processed as normal and may take additional days to ship.
HK
