Hybridization of ALK break probe to a lung adenocarcinoma tissue section showing positive translocation signal (1RG1R1G).
Hybridization of ALK break probe to a lung adenocarcinoma tissue section showing positive translocation signal (1RG1R1G).
RUO - ALK Break
Translocations of the ALK (anaplastic lymphoma kinase) gene at 2p23 have originally been associated with anaplastic lymphomas, B-cell lymphomas, neuroblastomas and myofibroblastic tumors. At least 21 translocation partners have been described, however 80% of the translocations involves the NPM1 gene (5q35). ALK rearrangements have been described in non-small cell lung cancer (NSCLC) cases. Multiple tyrosine kinsae inhibitors (TKI's) specific for ALK have since been approved for first line treatment of NSCLC-patients carrying the fusion gene ALK-EML4. These ALK inhibitors include crizotinib (Xalkori), alectinib (Alecensa) and ceritinib (Zykadia). The ALK (2p23) Break probe is optimized to detect translocations involving the ALK gene region at 2p23.
References: Soda et al, Nature, 2007, 448, 561-566. Kwak et al, J Clin Oncol., 27(26):4247-53. Koivunen et al, Clin Cancer Res, 2008, 14, 4275-4283.
