Advancing Cancer Diagnostics, Improving Lives
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Antigen Background
The Ki67 antigen is a nuclear protein that is expressed in all active phases of the cell cycle (G1, S, G2, and mitosis) but is absent in resting cells (G0). In contrast to many other cell cycle-associated proteins, the Ki67 antigen is consistently absent in quiescent cells and is not detectable during DNA repair processes. Thus, the presence of the Ki67 antigen is strictly associated with the cell cycle and confined to the nucleus, suggesting an important role in the maintenance and/or regulation of the cell division cycle.
Disclaimer
The Ki67 Antigen is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
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