Advancing Cancer Diagnostics, Improving Lives
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Antigen Background
DOG-1は986アミノ酸からなる機能未知のタンパクで、主に消化管間質腫瘍（GIST）の細胞膜に発現しています。形態学的にGISTと混同されやすい他の軟部組織腫瘍に発現するのはまれです。DOG-1 免疫反応性は、GISTの97.8%（KIT陰性含む）に認められると報告されています。DOG-1免疫反応性は、KIT 抗原を発現しない血小板由来増殖因子受容体Alphaの変異体も含めてGISTの診断に役立つことが示唆されています。
Product Specific Information
Clone K9 抗体の染色には、PBSをベースとした洗浄用緩衝液および抗体希釈液を使用すると、背景染色が強くなるため、弊社製品またはTBSをベースとした洗浄用緩衝液および抗体希釈液をご使用ください。
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