Advancing Cancer Diagnostics, Improving Lives
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Antigen Background
Cytokeratinは、上皮細胞に存在する中間径フィラメントタンパクです。正常臓器とそれらに由来する腫瘍に、組織特異的に発現しています。Cytokeratin 7はCytokeratinの中性／塩基性のタイプ II（TypeB）に属し、腺および移行上皮に分布します。Cytokeratin 7は、培養した気管支細胞および中皮細胞で豊富に発現していますが、培養表皮細胞での発現は低レベルであると報告されています。Cytokeratin 7は、膀胱癌と嫌色素性腎細胞癌に加えて、肺・乳腺・子宮内膜・卵巣・甲状腺の腺癌でも報告されています。Cytokeratin 7とCytokeratin 20の発現は、原発性および転移性肺腺癌と大腸腺癌で特徴的なパターンを示すことが報告されています。
Product Specific Information
Clone OV-TL 12/30 抗体では血管内皮細胞への反応が認められますが、Clone RN7抗体ではこの反応は認められません。Clone OV-TL 12/30抗体での染色では、最良な染色のため、抗原賦活液による熱処理や酵素処理など条件をご検討頂く必要があります。
Disclaimer
Cytokeratin 7 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
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