Advancing Cancer Diagnostics, Improving Lives
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Antigen Background
CD19は、免疫グロブリンスーパーファミリーに属し、2つの免疫グロブリン様ドメインを持っています。Bリンパ球と濾胞樹状細胞の表面に存在する単鎖糖タンパクです。CD19は、B細胞の発生、活性化および分化の重要な調節因子です。B細胞では、CD19はCD21、CD81 およびCD225（Leu-13）と会合し、シグナル伝達に関与する複合体を形成しています。CD19は、B細胞系の最も初期の段階から、分化成熟段階を通じて発現していますが、形質細胞へ成熟するときはその発現が失われます。
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