FGFR3 / IGH t(4;14) Fusion probe hybridized to MM patient material showing t(4;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.
FGFR3 / IGH t(4;14) Fusion probe hybridized to MM patient material showing t(4;14) translocation (2RG1R1G). Image kindly provided by Prof. Jauch, Heidelberg.
IVD FGFR3/IGH
The t(4;14) translocation is undetectable by conventional cytogenetics. The breakpoints on chromosome 4 occur within an approximately 113-kb region located in small part of a conserved gene cluster including the transforming acidic coiled-coil protein 3 (TACC3), fibroblast growth factor receptor 3 (FGFR3), and multiple myeloma SET domain-containing protein (MMSET). The translocation is indicative for poor survival and poor response to chemotherapy. The FGFR3/IGH t(4;14)(p16;q32) Fusion specific FISH probe is optimized to detect the reciprocal translocation t(4;14) in a dual-color, dual-fusion assay.
References: Chesi et al, 1997, Nat Genet, 16; 260-264. Finelli et al, 1999, Blood, 94; 724-732.
Produits
Produits
KBI-10602
ON FGFR3/IGH t(4;14) Fusion
Product is out of stock
Due to manufacturing & supply chain issues, this product is currently unavailable. You may place your order and it will be fulfilled when the product is back in stock. For more help, please reach out to customer service at +1 844 534 2262 or nonurgentcs@leicabiosystems.com
Nous avons un stock limité de ce produit
Nous avons un stock limité de ce produit, mais nos produits sont continuellement en fabrication. Votre commande sera traitée, mais le délai de livraison risque dêtre un peu plus long pour cette commande.
FR
