RUO - BCL2 Break (tissue)

Follicular lymphoma is a mature B-cell lymphoma characterized by the presence of the t(14;18) translocation that juxtaposes the BCL2 locus on chromosome 18q21 to the immunoglobulin H (IGH) locus on chromosome 14q32, resulting in the overexpression of the anti-apoptotic protein BCL2. Besides IGH, additional translocation partners to BCL2 have been identified. A break or split assay is therefore best suited to detect rearrangements of the BCL2 gene region at 18q21. The BCL2 (18q21) Break probe is optimized to detect translocations involving the BCL2 gene region at 18q21 in a dual-color, split assay on paraffin embedded tissue sections. Kreatech has developed this probe for the specific use on cell material (KBI-10612), or on tissue (KBI-10745).

References:
Taniwaki M et al, 1995, Blood, 86; 1481-1486.
Poetsch M et al, 1996, J Clin Oncol, 14; 963- 969.
Einers R et al, 2005, Am J Clin Pathol, 124; 421-429.