Programmed death-ligand 1 (PD-L1), CD274 or B7 Homolog 1(B7-H1) is a protein encoded by the CD274 gene. When bound to its ligands, PD-1 and B7.1, it plays an immunosuppressive role by inhibiting T-cell activity. Overexpression of PD-L1 by cancer cells may enable them to evade the host immune response, conferring a growth advantage to such tumours. PD-L1 expression levels detected by immunohistochemistry can therefore be of prognostic value in some types of cancer.
PD-L1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using nonimmunologic histochemical stains.
Disclaimer PD-L1 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.
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We are currently updating the product codes for a number of our Advanced Staining reagents. From January 2023 you will begin to receive products with a –U, –A or –X suffix (e.g. PAxxxx-U).
Due to manufacturing & supply chain issues, this product is currently unavailable. You may place your order and it will be fulfilled when the product is back in stock. For more help, please reach out to customer service at +1 844 534 2262 or nonurgentcs@leicabiosystems.com
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