LAG-3

Antigen Background
LAG-3 (Lymphocyte Activation gene 3, CD223) is a 503 amino acid transmembrane protein. It plays a role in the negative regulation of cellular proliferation & activation of T-cells in a similar manner to CTLA-4 and PD-1. LAG3 plays a role in the exhaustion of T-cell responses in cancer, and is therefore the subject of extensive research in conjunction with other related immunomodulatory markers.

Disclaimer
LAG-3 is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.