RUO - EGFR / SE 7

Epidermal growth factor receptor (EGFR) is a cell membrane protein, providing signal transduction and cell growth. It is a member of the Erb-B family of type I receptor tyrosine kinases and implicated in the development and progression of non-small cell lung carcinomas (NSCLC), breast, intestine, and other organs. EGFR has been found to act as a strong prognostic indicator in head and neck, ovarian, cervical, bladder and oesophageal cancers. In these cancers, increased EGFR expression was associated with reduced recurrence-free or overall survival. The EGFR (7p11) FISH probe is optimized to detect copy numbers of the EGFR gene region at region 7p11. The chromosome 7 satellite enumeration (SE 7) probe at D7Z1 is included to facilitate chromosome identification.

References:
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Nicholoset al, 2001, Eur J Cancer, 37: 9-15.